林敏钊

围绕肿瘤微环境调控、生物材料治疗策略开展系统研究，重点关注乳腺癌骨转移、肿瘤免疫协同治疗及局部治疗材料构建。更多成果可通过 ORCID 查看。

Injectable hydrogel induces tumor cell extracellular calcification and bone regeneration to disrupt the osteolytic vicious cycle in bone metastasis

构建可注射水凝胶体系，通过诱导肿瘤细胞胞外钙化并促进骨再生，实现对骨转移灶“抑瘤—修骨”的协同干预。发表于 Journal of Controlled Release，2026。

αPD-1-conjugated acid-cleavable nanodrugs overcomes cellular immunotherapy barriers in pancreatic tumors

构建 αPD-1 偶联酸敏纳米药物，用于突破胰腺肿瘤细胞免疫治疗中的递送与微环境屏障。发表于 Nature Communications，2026。

Overcoming chemoresistance in acute myeloid leukemia via co-delivery of siGLUT1 and hydroxycamptothecin using hyaluronic acid-conjugated nanocarriers

构建透明质酸偶联纳米载体，共递送 siGLUT1 与 hydroxycamptothecin，以改善急性髓系白血病的耐药问题。发表于 International Journal of Biological Macromolecules，2025。

A ROS/ultrasound dual-responsive nanocarrier enhances drug penetration for ameliorating metabolic dysfunction-associated steatohepatitis

发展 ROS/超声双响应纳米载体，以提高病灶渗透与治疗效率，体现了刺激响应型递送体系在复杂疾病微环境中的应用潜力。发表于 Acta Biomaterialia，2025。

Core-Satellite Nanoassembly Overcomes Spatial Heterogeneity of Dendric Cell Distribution in Pancreatic Tumors for Effective Chemoimmunotherapy

提出核心–卫星型纳米组装策略，用于克服胰腺肿瘤中树突状细胞空间分布异质性，增强化疗与免疫治疗的协同效应。发表于 ACS Nano，2025。

Light-inducible nanodrug-mediated photodynamic and anti-apoptotic synergy for enhanced immunotherapy in triple-negative breast cancer

构建光诱导纳米药物体系，通过光动力治疗与抗凋亡调控协同，增强三阴性乳腺癌免疫治疗效果。发表于 Biomaterials Science，2024。

A hierarchical tumor-targeting strategy for eliciting potent antitumor immunity against triple negative breast cancer

提出分级肿瘤靶向策略，用于增强三阴性乳腺癌中的抗肿瘤免疫效应，体现了递送路径设计与免疫激活协同优化的思路。发表于 Biomaterials，2023。

Nanodrug regulates ROS homeostasis via enhancing fatty acid oxidation and inhibiting autophagy to overcome tumor drug resistance

围绕 ROS 稳态、脂肪酸氧化与自噬调控，探索纳米药物克服肿瘤耐药的代谢干预路径。发表于 Biomaterials Science，2023。

Inflammation-Regulated Nanodrug Sensitizes Hepatocellular Carcinoma to Checkpoint Blockade Therapy by Reprogramming the Tumor Microenvironment

设计炎症响应型纳米药物，通过重塑肝癌肿瘤微环境，提高免疫检查点阻断治疗敏感性。发表于 ACS Applied Materials & Interfaces，2022。

One-step removal of harmful algal blooms by dual-functional flocculant based on self-branched chitosan integrated with flotation function

构建自分支壳聚糖双功能絮凝材料，实现有害藻华的一步高效去除，体现了在功能高分子材料设计方面的早期研究基础。发表于 Carbohydrate Polymers，2021。